MANUFACTURING

Chemical Reactions (traditional)
• Alkylation
• Cyclization
• Esterization
• Ring-closing reaction
• Williamson synthesis
• Phase-Transfer-Reaction
• Chlorination with Thionylchloride and/or Chlorsulfonic acid

Production Techniques (additional)
• Milling
• Mixing
• Crystallization
• Drying (packed bed as well as fluidized bed drying)
• Sieving

Chemical Reactions by Enzymes
Enzymical supported reactions
(patented and free available enzymes)
• Screening
• Evaluation
• Handling
• Upscale
• Production

Specialities
• Ability to use highly specific types of reactions, e.g. enzymatical catalyzed reactions
• Experience with regulatory affair activities (ASMF)
• Long time experience with APIs (e.g. used as thyreostatic or cardiovascular drugs)
• Process development
• Tech Transfer

HERBRAND PharmaChemicals GmbH · Brambachstraße 31 · D-77723 Gengenbach · Fon +49 7803 9687-0 · Fax +49 7803 9687-40.